Study of muscle biomarkers in hypothyroid patients

Background: Hypothyroidism is characterized by a decline in basal metabolic rate which can lead to glycogen build up and decreased enzyme activity energy synthesis other regulatory systems. Thyroid hormones have number of key targets including skeletal muscle. Thus, hypothyroid patients altered glycolysis, glycogenolysis mitochondrial metabolism an impact on muscle function. Timely assessment biomarkers Creatine Kinase (CK) (NAC) [N-acetyl-cystein], CK-MM, Lactate dehydrogenase (LDH), Aspartate Transaminase (AST) Aldolase hypothyroidism estimate the usefulness these enzymes as screening tests detect damage associated with hypothyroidism. Objective: To serum CK(NAC), LDH, AST compare normal healthy controls. Material Methods:The study was conducted Department Biochemistry, Teerthanker Mahaveer Medical College & Research Centre Moradabad. CK (NAC), were measured 60 under age group (20-60) years using automated method their levels compared individuals Results: Serum CK-MM significantly higher cases than controls (p